Large North American Multicenter Experience on Endoscopic Submucosal Dissection of Rectal Neoplasms Extending to the Dentate Line.
Abstract
INTRODUCTION: The ideal resection strategy for rectal neoplasms extending to the dentate line (RNDLs) remains unclear. Transanal surgical approaches and endoscopic mucosal resection (EMR) have their limitations related to inadequate visualization, device maneuverability, and securing an adequate margin on the anal side. Endoscopic submucosal dissection (ESD) appears to overcome some of the limitations of transanal surgical and snare-based endoscopic techniques. Therefore, we evaluated the safety and efficacy of ESD for resection of distal rectal lesions within 2 cm of the dentate line.
METHODS: This is a large-scale multicenter retrospective study of patients who underwent ESD for RNDLs between 2015 and 2023. The primary outcomes were the rates of R0 and en bloc resection. Secondary outcomes were immediate and delayed adverse events.
RESULTS: A total of 255 patients across 20 institutions were included (mean age 63.60, women 52.20%). The median lesion size was 40 mm (IQR: 30 to 55), and the median resection time was 110 minutes (IQR: 81 to 169). The en bloc resection rate was 93.70% (n=236), and the rate of R0 resection was 85.40% (n=216). The rate of overall adverse events was 8.70% (n=22, 95% CI: 5.22% to 12.17%), with 13 cases of bleeding (5.10%), 4 cases of full-thickness perforation, and 1 case of postprocedural pain requiring intervention. All AEs were managed conservatively without the need for subsequent surgical or endoscopic interventions.
CONCLUSIONS: ESD is safe and effective for resecting RNDLs with high en bloc and R0 resection rates, offering the potential for complete resection with minimal morbidity. It offers advantages over TEN, TAMIS, and other forms of transanal surgery due to the anatomy being less conducive to the equipment required for these techniques, lower cost, and lower rates of complications. However, careful patient selection, meticulous procedural planning, and close follow-up are essential to ensure optimal outcomes and minimize the risk of complications. Long-term follow-up studies and additional prospective controlled trials are warranted.
Document Type
Article
Publication Date
10-29-2025
Publication Title
Journal of clinical gastroenterology
Recommended Citation
Sharma, Neil R; Gopakumar, Harishankar; Malik, Talia F; Khan, Aqsa; Dahiya, Dushyant S; Vohra, Ishaan; Zelt, Christina; Rumple, Ashley RN, BSN; Flanagan, Mindy; Mendoza-Ladd, Antonio; Adam, Abdul A; Saeed, Ahmed B; Othman, Mohamed; Ngamruengphong, Saowanee; Arayakarnkul, Suchapa; Bhatt, Amit; Yang, Dennis; Bilal, Mohammad; Rojas De Leon, Mariajose; Schlachterman, Alexander; Madaka, Pranita; Kamal, Faisal; Kumar, Anand; Thompson, Blake; Kedia, Prashant; Diehl, David; Shah, Sagar; Sedarat, Alireza; Wang, Andrew Y; Dhaliwal, Amaninder; Pannu, Davinderbir S; Mizrahi, Meir; Kahaleh, Michel; Andrawes, Sherif; and Draganov, Peter V, "Large North American Multicenter Experience on Endoscopic Submucosal Dissection of Rectal Neoplasms Extending to the Dentate Line." (2025). PCI Publications and Projects. 107.
https://researchrepository.parkviewhealth.org/oncol/107