Gastric Gastrointestinal Stromal Tumors (GIST): a Case Series and Current State of the Art in the Workup and Treatment of This Rare Disease

Neil Sharma, Parkview Cancer Institute
Harishankar Gopakumar, Parkview Health
Nancy Ehmke, Parkview Cancer Institute


Research Key Highlights

• Gastrointestinal stromal tumors (GISTs) are uncommon intramural tumors of the GI tract. They are most often seen in the stomach and arise from the muscular layers of the visceral wall.

• The clinical manifestations of GISTs vary depending on the tumor size and location, but are often asymptomatic.

• Advances in endosonography (EUS) and immunohistochemical staining can distinguish these lesions from other intramural and GI tract tumors and are an essential part of the diagnostic and staging workup.

• The advent of EUS-guided fine needle biopsy (FNB) allows for large core tissue acquisition. This has replaced FNA and allowed for histologic analysis of large specimens, increased IHC confirmation, and personalized medicine.

• Treatment involves surgical, endoscopic or hybrid endoscopiclaparoscopic resection. Imatinib may be given, and lesions less than 2 cm may be observed.

• The cases presented in this report represent pathology-confirmed GISTs diagnosed at a large volume, community, tertiary referral GI oncology program during July 2012 through May 2016. Follow-ups for each patient have discovered no recurrences to date.