Background and Objective:
Urosepsis is an infection that originates from the urinary tract and accounts for 9% of all sepsis cases. 1 Pathogens commonly associated with urosepsis include E. coli, Proteus spp., Enterobacter spp., Klebsiella spp., and P. aeruginosa, and gram-positive bacteria (5% of cases). Sepsis treatment guidelines do not provide specific recommendations for the management of urosepsis; however, they state to utilize anti-MRSA agents, such as vancomycin, when risk factors for MRSA exist. 2 The prevalence of urosepsis caused by gram-positive organisms has been reported at low rates. The objective of this study is to evaluate how often vancomycin is used empirically in patients with urosepsis and the outcomes that are associated with its use.
Stump, Curtis PharmD; Mohmed, Shahinda; and Linn, Dustin D PharmD, RPh, BCCCP, "An Evaluation of Vancomycin Use in Patients with Urosepsis" (2020). Pharmacy. 47.