A phase I/II study of pemetrexed with sirolimus in advanced, previously treated non-small cell lung cancer.
Background: Single-agent pemetrexed is a treatment for recurrent non-squamous non-small cell lung cancer (NSCLC) that provides limited benefit. Preclinical studies showed promising synergistic effects when the mammalian target of rapamycin (mTOR) inhibitor sirolimus was added to pemetrexed.
Methods: This was a single-institution phase I/II study of pemetrexed in combination with sirolimus. The primary endpoint for the phase I was to determine the maximum tolerated dose (MTD) and safety of the combination. The primary endpoint for the phase II portion was to determine the overall response rate at the MTD. Key eligibility criteria included recurrent, metastatic NSCLC, ECOG performance status of 0-2, and adequate organ function. Sirolimus was administered orally daily after an initial loading dose, and pemetrexed was given intravenously on day 1 of every 21-day cycle.
Results: Forty-two patients with recurrent, metastatic NSCLC were enrolled, 22 in phase I and 20 in phase II. The MTD was pemetrexed 500 mg/m
Conclusions: The combination of pemetrexed and sirolimus is active in heavily-pretreated NSCLC (ClinicalTrials.gov Identifier: NCT00923273).
Transl Lung Cancer Res
Komiya, Takefumi MD; Memmott, Regan M; Blumenthal, Gideon M; Bernstein, Wendy; Ballas, Marc S; De Chowdhury, Roopa; Chun, Guinevere; Peer, Cody J; Figg, William D; Liewehr, David J; Steinberg, Seth M; Giaccone, Giuseppe; Szabo, Eva; Kawabata, Shigeru; Tsurutani, Junji; Rajan, Arun; and Dennis, Phillip A, "A phase I/II study of pemetrexed with sirolimus in advanced, previously treated non-small cell lung cancer." (2019). Oncology Publications. 38.