Prognostic and Predictive Value of KRAS Mutation in NSCLC.
...we suggest another biological pathway that is associated with EGFR/KRAS signaling. Liver kinase B1 gene (LKB1), a serine/threonine kinase, is a frequently mutated tumor suppressor gene in NSCLC... Refers to: Alona Zer, Keyue Ding, Siow Ming Lee, Glenwood D. Goss, Lesley Seymour, Peter M. Ellis, Allan Hackshaw, Penelope A. Bradbury, Lei Han, Christopher J. O’Callaghan, Ming-Sound Tsao, Frances A. Shepherd
Pooled Analysis of the Prognostic and Predictive Value of KRAS Mutation Status and Mutation Subtype in Patients with Non–Small Cell Lung Cancer Treated with Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors Journal of Thoracic Oncology, Volume 11, Issue 3, March 2016, Pages 312-323
Letter to the Editor
J Thorac Oncol
Yamamoto, Satomi; Washington, Laurie; and Komiya, Takefumi MD, "Prognostic and Predictive Value of KRAS Mutation in NSCLC." (2016). Oncology. 22.