Endoscopic Mucosal Resection of Granular Cell Tumors in the Esophagus: a Study of Four Cases and Brief Literature Review


, GCTs are extremely rare lesions that can affect the esophagus. Although all of our cases presented with gastrointestinal symptoms, it is likely that GCTs are much more prevalent than what is documented in the literature, given their indolent nature. Tumors greater than 2 cm may require more extensive resection with endoscopic submucosal dissection (ESD) which may allow for en bloc resection of larger lesions. Because these lesions are usually confined to layers 1 through 3 (mucosa to submucosa), almost all should be amendable to advanced endoscopic resection techniques which reduce morbidity and cost for patients compared to conventional surgical options. Complications and R0 resection are operator dependent and complication rates are decreased in the setting of an experienced advanced interventional endoscopist. Our experience with EMR helps to prove that it is a safe and effective treatment option for GCTs. Although our follow-up is limited, we have not experienced any complications or recurrences. EMR is a low-risk, efficacious treatment that can be used to resect GCTs confined to the mucosal and submucosal layers.

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